Abstract: Capable talents are the engine to promote high-quality development, and so stimulating talents' innovative vitality is an important support for scientific and technological revolution. Developing human resources is the key breakthrough for enterprises to rescue and enhance innovative vitality. Taking the employees of science and technology start-ups in Shanghai and Shenzhen as research sample, this paper explores the role of three dimensions of human resource management intensity in the process of employee innovative behavior, as well as the regulatory role of differential order atmosphere and the intermediary role of organizational support. The results show that the three dimensions of human resource management intensity have a positive impact on employees' innovative behavior; the sense of organizational support plays a mediating role in relationship between the three dimensions of human resource management intensity and employees' innovative behavior; differential order atmosphere plays a negative regulatory role in relationship between the three dimensions of human resource management intensity and organizational support. This study has certain enlightenment for organizations to improve the intensity of human resources management from the perspective of employees' psychological cognition, promote employees' innovative behavior, reduce the ripple effect of difference order and strengthen the “concentric circle” of talents.