Abstract: Medical device industry is an interdisciplinary and knowledge-intensive industry which needs collaborative innovation of professionals from different domains. Through literature review, this paper concludes that there are some problems in collaborative innovation of medical devices, such as low achievement transformation performance, high cost of registration and approval, imperfect intellectual property protection mechanism, asymmetric information and defects of incentive mechanism, etc. Hash encryption technology of Blockchain, difficulty in tampering and traceability of data documents and smart contract technology provide the possibility to solve the problems existing in collaborative innovation of medical devices. Based on the above analysis, this paper gets a solution based on Blockchain to solve the problems in the field of collaborative innovation of medical devices. The framework of the scheme includes two levels: intellectual property incentive system and data management system.