Abstract: For the structural safety of a centrifugal impeller, the strength of the impeller is collaboratively simulated using CFD and static structure analysis modules in ANSYS Workbench package.Three dimensional models of impeller and flow domain are created based on feature modeling method of SolidWorks.Data transfer between flow filed and structural field is realized through FSI interface to realize a fluid pressure calculation.The results show that the impeller meets the strength requirements, and the fluid pressure on the impeller has significant effect upon structure safety.