Abstract: A new heterocyclic amide derivative N-(benzodthiazol-2-yl)furan-2-carboxamide was synthesized according to the principle of bioactive substructure combination using furan-2-carboxylic acid and 2-amino-benzothiazole as raw materials, and its antifungal activity against five plant pathogenic fungi (Rhizoctonia solani, Botrytis cinerea, Gibberella zeae, Helminthosporium maydis and Sclerotinia sclerotiorum) was tested. Results show that the synthesized target compound reveals excellent antifungal activity against the five fungi. Among them, its anti-activity against Helminthosporium maydi, Botrytis cinerea and Sclerotinia sclerotiorum is better than carbendazim. Meanwhile, its structure is confirmed by ¹H NMR and ¹³C NMR.