Effects of Pomegranate Peel Extract on Liver Antioxidant Defense Function in Experimental Diabetic Mice

TO study the effect of pomegranate peel extract on liver antioxidant ability in experimental diabetic mice, diabetic mice were treated with pomegranate peel extract (0.2、0.4、0.8g / kg.BW) respectively. After 5 weeks, the commonly status, liver antioxidant ability and the change of livers histological were observed. The treatment diabetic mice groups of pomegranate peel extract were compared with the experimental diabetic mice group. The level of blood glucose was reduced significantly(P < 0.05), maleic dialdehyde(MDA), Glutathione peroxidase (GSHPx) and catalase (CAT) were reduced significantly(P < 0.01), Superoxide dismutase (SOD) and the levels of glutathione(GSH) of high doses was increased remarkably(P < 0.05). nitric oxide synthase(NOS) of low doses was reduced significantly(P < 0.01), nitric oxide (NO) and glutathione S-transferase(GST) were not different.The liver histological damages of pomegranate peel extract treatment group were abated with DM group under light microscope observation. The extract of pomegranate peel can effectively enhance the liver antioxidant function and protect liver cells, decrease liver cell damages.