The Synthesis of 3-hydroxy-5-methoxy Pyridine

3-hydroxyl-5-methoxyl pyridine is an important intermediate of drug. It is valuable to research the synthetic process.In this paper, four synthesis routes of 3-hydroxyl-5-methoxyl pyridine, which used 3, 5-dibromopyridine and N-benzyl glycine ethyl ester as raw materials, were studied.Among them, the 3-hydroxyl-5-methoxyl pyridine was successfully synthesized by the five step reaction process of methyletherification, nitrogen oxidation, aminolysis, denitrification and nitrification and hydrolysis 3, 5-dibromopyridine was used as raw material with a total yield of 66.7%.The structure of aim compound was characterized by ¹H NMR, IR, MS and X-ray single crystal. This synthesis method is simple with an ideal yield.It can provide reference for the industrial production of aim products.