Determination of Seven Kinds of Sulfonamides Residues in Royal Jelly by UPLC-MS/MS

WANG Wei; YOU Cuiping

doi:10.3969/j.issn.1673-159X.2019.03.013

WANG Wei, YOU Cuiping. Determination of Seven Kinds of Sulfonamides Residues in Royal Jelly by UPLC-MS/MS[J]. Journal of Xihua University(Natural Science Edition), 2019, 38(3): 78-81. DOI: 10.3969/j.issn.1673-159X.2019.03.013

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Determination of Seven Kinds of Sulfonamides Residues in Royal Jelly by UPLC-MS/MS

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ObjectiveTo establish a method of ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) for the simultaneous determination of seven kinds of sulfonamides.
MethodsAfter honey was extracted by acetonitrile:water(80:20), the extraction was quickly purified by HLB and analyzed by UPLC-MS/MS.The qualitative and quantitative analysis of the compounds was carried out under the multi-reaction monitoring(MRM) modein matrix-matched standard method.
ResultsIt shows a good linearity(r²>0.99) for all compounds.The LOD values of antibiotics and pesticides were in the range of 0.5~8.0 μg/kg.The LOQs of antibiotics and pesticides were in the range of 1.0~10.0 μg/kg.At the three spiking levels, the recoveries ranged in 79.29%~102.63% with relative standard deviations of 2.5%~8.4%.
ConclusionThe proposed method was simple, rapid, sensetive and accurate, and it could fit for the requirements of residue analysis.

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Determination of Seven Kinds of Sulfonamides Residues in Royal Jelly by UPLC-MS/MS

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