Abstract: The paper begins with the discussion of the theoretical basis of human nature and community of human destiny guided by Marxist theory and “real community”; it also explores the standardization of the community of human destiny and the structure of comprehensive health with correct concept of Yi(Yi means value and goal) and benefit; and then, it constructs a matrix structure of the community of shared future for human comprehensive health under the community of human destiny based on the knot points of coexistence, co-connection, co-unification, co-convergence, co-conservation, co-ownership, shared and symbiotic relationship of the two structures. Based on the above discussion, the paper applies the principle of Yi-zhi to transform the common structure of comprehensive health governance so as to eliminate the factors violating Yi, and it gets the matrix structure of “pure Yi” comprehensive health community that meets the requirements of Yi value and reaches the goal of Yi-zhi through counter evidence. Finally, the paper substitutes the essential characteristic elements (matrix) of the community of human destiny, the structure of comprehensive health and the community of shared future for human comprehensive health into the matrix of “pure Yi”, and obtains the countermeasure matrix composed of 512 cooperation points of all kinds of comprehensive health subjects.