Abstract: Industrial structure supererogation is an effective way to promote high-quality economic development. As the vanguard of high-quality economic development, coordinated industrial development in the Yangtze River Economic Belt is essential. Taking the panel data of prefecture-level cities from 2003 to 2018 as research samples, this paper investigates the spatial network characteristics of the industrial structure of the Yangtze River Economic Belt by using social network analysis method, and integrates the indicators reflecting the spatial network characteristics into the spatial econometric model to explore the influencing factors of the industrial structure of the Yangtze River Economic Belt. The study finds that the overall network relevance of the industrial structure of the Yangtze River Economic Belt is high, and its compactness is constantly enhanced and its stability is constantly improved. In this spatial network, Shanghai, Chongqing and Wuhan are at the core positions and have strong communication, domination, and information transmission capabilities. In addition, there is an obvious spatial spillover effect in the heightening of industrial structure, and the enhancement of regional communication ability and dominance and the independence of inter-regional information transfer in spatial network are beneficial to improve the level of industrial structure supererogation. Therefore, when formulating industrial policies, each region must shift from "local" to "overall", and find a path for industrial structure transformation and upgrading according to its "position".