Abstract: The regional heterogeneity of China's economic development is obvious. Under the background of ecological civilization construction and sustainable development, it is of great significance to explore regional differences of haze pollution and its relationship with economic growth. Based on Dagum Gini coefficient and Tapio model, this paper studies regional differences of haze concentration and its decoupling from economic growth in China from 2015 to 2020. The results show that: 1) The PM2.5 concentration in economic zones shows an obvious downward trend, with characteristics of "higher in the north and lower in the south, and higher in the east and lower in the west", while the seasonal change with characteristics of "higher in winter and lower in summer". 2) The regional differences of overall PM2.5 concentration tend to expand as the inter-regional difference is the main source of overall regional difference. The regional differences in the Southwest economic zone have an obvious expanding trend, the regional differences in the Middle Yangtze River economic zone have an obvious narrowing trend, and the gap between the middle reaches of the Yellow River and the Yangtze River, and other economic zones is still expanding significantly. 3) The decoupling relationship between haze concentration and economic growth in most areas shows a strong decoupling state, but the decoupling state is not sustainable and the decoupling stability is poor.