Abstract: Substance abusers usually have adverse experiences in childhood. The young-age trauma is an influential factor for most drug users to be addictive or even relapse after treatment. By using the Adverse Childhood Experience (ACEs) questionnaire and self-designed data collection form, the present study investigates and analyzes the adverse childhood experiences of female drug users in a drug rehab center. The study shows that the female drug users were commonly traumatized in childhood, mainly due to dysfunctional family relationships, emotional neglects and emotional abuse. It also shows that these female drug users' traumatic experiences in the young age have a significant impact on the ages of their first drug use, years of addiction, and levels of education. The study suggests that we should put more effort to create a trauma-based psychological treatment system and correction framework when doing psychotherapy in the female rehabilitation center, so as to enhance their emotional stability and improve the way of coping with psychological distress. Meanwhile, we should help to create a harmonious community and family life to prevent the adverse childhood experiences from happening.