Abstract: With the high-quality development of China’s economy, drug control has remarkable achievements, but the number of drug addicts continues to increase in China. Compared with male drug addicts, female drug addicts are more likely to take drugs due to increased work and social pressure. Therefore, it is of great significance to study the personality characteristics of female forced drug rehabilitation personnel and the factors that affect the differences in EPQ characteristics of female forced drug rehabilitation personnel, so as to provide more targeted, scientific and effective management and treatment interventions for those under compulsory treatment. By using the basic information questionnaire and the Eysenck Personality Questionnaire (EPQ), the paper investigates and analyzes the basic information and personality characteristics of the compulsory isolation drug rehabilitation personnel. The results show that different ways of communication and intervention should be adopted for different temperament types of female drug users, and personalized psychological treatment programs should be formulated for them.