Abstract: Development of information and technology has created more new multimodal discourse forms, whose diversity and complexity make the study of multimodal discourse from perspective of interdiscipline become inevitable. Currently, the interdisciplinary research of multimodal discourse is in its infancy. The interactive research with social semiotics, sociology, cognitive science, anthropology, ethnology, communication studies, philosophy, computer science, has achieved some success. Meanwhile, there also exist problems: narrowness of interdisciplinary research dimension, lack of depth, shortness of empirical research, hysteresis of interdisciplinary team building and interdisciplinary talents training, insufficiency of domestic research. Finally, the paper put forward some suggestions: the coming research should focus on interdisciplinary team building and interdisciplinary talents training in terms of the interdisciplinary research of multimodal discourse, and put emphasis on microscopic and empirical study.